報(bào)告題目：Glycosciences: From Synthetic Methods to Glycobiology
糖科學(xué)：從糖合成到糖生物學(xué)
報(bào) 告 人：劉學(xué)偉 副教授 (Assoc. Prof. Liu Xuewei)
報(bào)告時(shí)間：2014年4月21日（周一）16：00-17：30
報(bào)告地點(diǎn)：化學(xué)樓二樓一號(hào)會(huì)議室
報(bào)告人簡(jiǎn)歷：
劉學(xué)偉，博士，新加坡南洋理工大學(xué)副教授，本科就讀于中國(guó)農(nóng)業(yè)大學(xué)化學(xué)系，1996年在中國(guó)農(nóng)業(yè)大學(xué)獲得碩士學(xué)位，2000年獲得南加州大學(xué)化學(xué)系博士學(xué)位，先后在美國(guó)P&G、Chugai Pharma 等公司任職，2003至2005年在加州理工學(xué)院做博士后研究，2006年1月起在南洋理工大學(xué)化學(xué)與生物化學(xué)系任助理教授（Assist. Prof）, 2012年起任副教授（Assoc. Prof）。主要研究方向包括有機(jī)合成化學(xué)、糖化學(xué)、糖生物學(xué)、藥物化學(xué)及功能性材料化學(xué)，目前獲得研究經(jīng)費(fèi)超過(guò)2000,000新幣，在世界知名期刊發(fā)表論文百余篇，其中包括3篇J. Am. Chem. Soc., 5篇Angew. Chem. Int. Ed., 2篇Adv. Mater., 1篇Chem. Soc, Rev.。多篇文章被ACS Chemical & Engineering News, nature publishing group, Angewandte, Synfacts, ChemistryViews 等highlight和評(píng)論。
學(xué)術(shù)兼職：
2002年-至今 美國(guó)紐約科學(xué)院成員
2012年-至今 亞洲糖生物學(xué)和糖工程通信(ACGG)指導(dǎo)委員會(huì)成員
2013年-至今 《中國(guó)藥學(xué)》英文版 編委
獲獎(jiǎng)：
2006 The 1st Asian Core Program (ACP) Lectureship Award (to Japan)
2007 Excellent Presentation Award, Thailand
2009 Young Researcher Award
2011The 6th Asian Core Program (ACP) Lectureship Award (to Korea)
2011The 6th Asian Core Program (ACP) Lectureship Award (to Taiwan)
2012 CoS Collaborative Research Award
The 7th Asian Core Program (ACP) Lectureship Award (to China)
Abstarct:
Ubiquitously decked on the surfaces of all cell types in nature, oligosaccharide molecules play central roles in the development, cooperation and vitality of an organism. Multitudinous approaches to make glycosidic bonds in a highly stereoselective manner have speedingly emerged for the last two decades. Nonetheless, an efficient and universal method to confidently synthesize various glycoconjugates have yet been established, especially one that is applicable for large scale and combinatorial chemistry. There are many reasons for the nascent state of carbohydrate researches, including the advent formation of new stereogenic center after every glycosylation step, the arduous characterization and purification thereafter, as well as the common expression of carbohydrate chains in a nonlinear, branched fashion. Extensive efforts are ongoing in our research group to overcome these challenges. Here, we present direct and reliable synthetic approaches that readily provides oligosaccharides and C-glycosides with not only exclusive anomeric stereoselectivity but also a wide range of derivatizations. Based on our synthetic expertise, we have developed new systems for sensing cellular proteins and events.
